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KMID : 0043319940170020057
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Archives of Pharmacal Research
1994 Volume.17 No. 2 p.57 ~ p.59
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Effect of Sodium Taurodihydrofusidate on Nasal Drug Delivery: Differences in Its Concentration and Penetrant Molecular Weight
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Hosoya Ken-ichi
Kubo Hiroyuki
Takashi-Akutsu
Hideshi-Natsume
Kenji-Sugibayashi
Yasunori-Morimoto
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Abstract
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The effect of sodium taurodihydrofusidate (STDHF) on drug permeation across nasal mucosa was studied in vitro using Ussing type diffusion chamber. Disodium cromoglicate (DSCG, M.W.5123) and fluorescein isothiocyanate-dextran (FD) of different molecular wieghts (M.W. 4400-71200) were used as model drugs. Pemeation profiles of DSCG and FDs showed a typical pseudo steady-state curve with short lag time. The pemeability coefficient of FD (M.W. 9400) sigmodially increased with increasing STDHF concentration. It also enhanced the DSCG pemeation. Interestingly the enhancement efficacy was independent of molecular weight of penetrants.
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KEYWORD
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Abosorption enhancer, Sodium taurodihydrofusidate, Ussing chamber, Nasal mucosa, Nasal delivery
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